I'm at work, so I can't do the tests now, but I think it is useful to make some considerations:
1) RuneAudio, via its interface, works like a charm. I played music from a powered HDD without any problem and, when I tried it, I didn't have to change anything in the config.txt.
2) I'm pretty sure that the spotifyd files are in the correct paths.
3) I would tend to exclude that the problem could be in spotifyd.conf, considering that "Every field is optional; Spotifyd can even run without a configuration file" (
https://github.com/Spotifyd/spotifyd)
4) The .service file is in folder path /usr/lib/systemd/system/ and, as you can see in the picture in my first post, it seems to be correctly found and loaded, but it stops immediately. So I think there is something wrong with this service, and maybe the log part I attached could be useful to find what causes the problem.